Enjoyment and Cannabis | Research
- OUI Editorial Staff
- Aug 19, 2024
- 3 min read
Updated: Aug 23, 2024
How Cannabis Supports JOY
The ECS (endocannabinoid system) is a complex cell-signaling system that helps regulate various physiological processes, including pain perception, mood, appetite, and immune function. Cannabinoids, both endogenous (produced naturally within the body) and exogenous (introduced from external sources like cannabis), play a significant role in regulating and supporting serotonin and those happy euphoria chemicals.
This Is Not Your Grandmother's "Grass"
Today's cannabis, especially in the regulated "recreational" market, is a well-researched and carefully constructed product for consumption. This isn't a baggie of oregano-looking, stinky "grass" that either made you giggle, shrink into an anxious ball, or just cough. Consistency in flavor and effect is the highest aspiration of every brand we bring to the OUI community. The products OUI recommends go through rigorous state testing (in California) to ensure they are safe and made from the highest quality ingredients. These products give you the most control, even when you're looking to let loose.
Control How You Feel
Responsible products all list their ingredients, and the amounts of THC in a product are HIGHLY regulated so that you can control how you feel. This is because the THC or Delta-9 molecule is the one that makes you "high."
Always start Low and Slow.
Micro-Dose: 2.5 - 5mg THC
Dose: 5 -10mg THC *
*depending on size, weight, and metabolism. Explore what level is right for you.
Edible products can take up to 90 minutes for the onset of effects and will be in your system for 4-6 hours
Beverages can take up to 30 minutes for the onset of effects and will be in your system for 4-6 hours (like alcohol)
Tinctures can take up to 60 minutes for the onset of effects and will be in your system 4-6 hours
OUID, Flower, and Vape can take up to 20 minutes for the onset of effects and will be in your system for 1-3 hours.
Potential Risks
If you are taking SSRI, SNRI, Buproprion, Buspirone, and Mirtazapine.
OUI insists you speak to your provider about cannabis. While most medications and moderate to low cannabis use are "safe", brain Chemistry is a beautiful complex flower that requires thoughtful care.

(Leafly: Jeremy Kossen Published on June 23, 2022· Last updated September 13, 2022)
TOO HIGH!
OUI suggests when exploring the Enjoy category, you pick up a CBD vape pen. CBD and THC are the ultimate power couple, they perfectly complement and balance each other out. It is possible to get "too high" and it feels terrible! To quickly pull back those feelings 2-3 puffs of CBD will bring you back to balance.
Can I O.D. on cannabis?
There has not been a reported overdose from Cannabis, alone.
There are plenty of overdoses with opioids, alcohol, cocaine, and other street drugs but never cannabis alone.
If you overdo it can be very unpleasant, and in rare cases, adult Cannabis over-use has led to medical intervention.
One serious, yet extremely rare physical issue caused by cannabis is Cannabinoid hyperemesis syndrome (CHS) which is caused by long-term cannabis (marijuana) use. Hyperemesis means severe vomiting. People who have CHS experience repeated and severe bouts of nausea, vomiting, dehydration, and stomach pain. In the case of CHS most medical practitioners will prescribe immediate cessation of cannabis, and will also recommend you look into Cannabis Use Disorder or CUD, which affects approx. 10% of the 193 million cannabis users worldwide. Typically CUD is found in the adolescent population. and family support practitioners recommend immediate cessation of cannabis for anyone under the age of 21, unless under medical supervision.
The Science
Here's how THC interacts with the ECS to create laughter:
THC binds to cannabinoid receptors: When consumed, THC binds to cannabinoid receptors (CB1 and CB2) in the brain and throughout the body. CB1 receptors are primarily found in the central nervous system, including areas of the brain involved in emotion, pleasure, and laughter, such as the limbic system and prefrontal cortex.
Neurotransmitter release: THC's interaction with CB1 receptors can lead to increased release of neurotransmitters like dopamine and serotonin, which are associated with feelings of happiness, pleasure, and well-being. This release of neurotransmitters can contribute to the euphoric and laughter-inducing effects of THC.
Altered perception and reduced inhibition: THC can also alter sensory perception, leading to an enhanced appreciation of humor and a greater likelihood of finding things funny. Additionally, THC may reduce inhibition and increase sociability, making users more prone to laughter and social bonding.
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