Seizures | Best For

Cannabis and Cannabinoids: Promising Research in Neurological Disorders

At OUI, we're excited about the revolutionary potential of cannabis in neurological disorders, particularly in managing seizures, epilepsy, and muscle spasms. Cannabis and its diverse cannabinoids are emerging as promising alternatives or complements to traditional treatments. From treatment-resistant epilepsy to multiple sclerosis-related spasticity, these natural compounds show potential in not just reducing symptoms but possibly altering disease trajectories.

Cannabinoids, the active compounds in cannabis, demonstrate remarkable effects on neuronal excitability and muscle tension through multiple mechanisms. Research indicates that CBD, in particular, has potent anti-seizure properties, leading to FDA approval of a CBD-based medication for certain forms of epilepsy. THC shows promise in reducing muscle spasticity, while THCV is being studied for its potential anti-convulsant effects.

Anti-Seizure Properties

Cannabis, particularly CBD, has shown remarkable potential in reducing the frequency and severity of seizures. Studies have demonstrated that CBD can interact with the body's endocannabinoid system to help regulate neuronal excitability. This mechanism may explain its ability to reduce seizure activity in various forms of epilepsy, including treatment-resistant cases.

Anti-Epileptic Effects

The anti-epileptic properties of cannabis extend beyond just CBD. While CBD remains the most studied cannabinoid for epilepsy, research is also exploring how THC, THCV, and CBG might contribute to managing epileptic conditions. These cannabinoids may work synergistically to provide more comprehensive seizure control and improve quality of life for individuals with epilepsy.

Anti-Spasmodic Qualities

Cannabis and its cannabinoids have shown promise in treating muscle spasticity associated with conditions like multiple sclerosis and spinal cord injuries. THC, in particular, has demonstrated the ability to reduce muscle stiffness and spasms. CBD may also contribute to these effects, potentially offering relief with fewer psychoactive side effects than THC alone.

The Science & Research

Studies suggest cannabinoids can modulate neurotransmitter release, influence ion channels, and affect neuronal excitability patterns. CBD may reduce seizures by enhancing the activity of inhibitory neurotransmitters and modulating calcium channels. THC's interaction with CB1 receptors appears to play a crucial role in its anti-spasmodic effects. CBG and CBC are also being investigated for their potential to support neuronal health and function.

Increasingly, patients with epilepsy, multiple sclerosis, and other conditions characterized by seizures or muscle spasms are turning to cannabis-based treatments.

For treatment-resistant epilepsy, CBD has shown significant promise in reducing seizure frequency. In multiple sclerosis, THC and CBD combinations have demonstrated effectiveness in alleviating spasticity and associated pain.

While research continues, the anti-seizure, anti-epileptic, and anti-spasmodic properties of cannabinoids offer an exciting avenue for managing these challenging neurological conditions.

OUI provides access to information and research. We are editors, curators, and cannasseurs; we are NOT doctors. ALWAYS DISCUSS CANNABIS USE WITH YOUR HEALTHCARE PROVIDER. Please contact us with any questions about access to research that you can share with your provider.